Mode of Genetic Inheritance
The pattern of inheritance of Charcot-Marie-Tooth disease according to NIH most cases of Charcot-Marie-Tooth disease is inherited in different ways and impact different ways like CMT1 and CMT2. “CMT2 is caused by direct damage to the nerve axon itself in comparison to CMT1 which results from damage to the myelin sheath insulating the axon. CMT2 is commonly referred to as “axonal” CMT. CMT2A is the most common subtype of CMT2 and is caused by defects in the MFN2 gene.”